varenicline is a partial agonist of the α4β2 subtype of the nicotinic acetylcholine receptor. in addition it acts on α3β4 and weakly on α3β2 and α6-containing receptors. a full agonism was displayed on α7-receptors.[4]
acting as an agonist varenicline binds to, and partially stimulates, the receptor without creating a full nicotine effect on the release of dopamine. varenicline also competitively binds to α4β2receptors blocking the ability of nicotine to stimulate the central nervous mesolimbic dopamine system.
indeed.
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