a lady friend has suggested that we apply for and acquire a native civilian award. pertinent to note that the action to be taken is in the form of an application rather than wait for the bell of destiny to toll! such is the state of affairs in an hitherto peerless recognition. we do not wish to sound like mr. mehta so shall avoid the puce-faced pontification at this juncture.
we were happy to have had the conversation with our lady friend - left us en bonne humeur after a trying day at the shop. we earnestly hope these conversations continue apace and that a viva voce is imminent!
what say lady friend?
Sunday, April 11, 2010
Saturday, April 10, 2010
some more things we love reading post-lunch
varenicline is a partial agonist of the α4β2 subtype of the nicotinic acetylcholine receptor. in addition it acts on α3β4 and weakly on α3β2 and α6-containing receptors. a full agonism was displayed on α7-receptors.[4]
acting as an agonist varenicline binds to, and partially stimulates, the receptor without creating a full nicotine effect on the release of dopamine. varenicline also competitively binds to α4β2receptors blocking the ability of nicotine to stimulate the central nervous mesolimbic dopamine system.
indeed.
Wednesday, April 07, 2010
whither mid-life crisis...
some people suffer MLC, some acquire MLC and some have MLC thrust upon them.
our question: when life has not commenced, whither MLC?
but we do seem to be displaying certain traits which could be classified under MLC:
- irritability
- inability to sustain or start meaningful relationships
- lack of focus
- no interest in previously enjoyed hobbies / pastimes / activities
- emotional coldness
- feeling of being overwhelmed at work or in personal situations [feeling out of control]
- inattentiveness
- sexual frustration
- lack of motivation
so what do we do with all these decidedly inelegant trappings? so far we have favoured escapism - preferring our own company, refusing opportunities for social outings, staying indoors with a book, auto-satisfaction... we also sometimes wonder whether we are like this due to tiredness, getting into situations or mindsets that create angst / torpor / feelings of inadequacy. we find ourself getting increasingly bogged down and stuck in a mindless routine that adds no value to our life.
we sometimes feel we need a goal. a focus. perhaps this should be explored.
the reason this post is in a blog on dobuy? our current lifestyle and situation emanate from our work conditions. which are not to our liking.
we will explore this further...
our question: when life has not commenced, whither MLC?
but we do seem to be displaying certain traits which could be classified under MLC:
- irritability
- inability to sustain or start meaningful relationships
- lack of focus
- no interest in previously enjoyed hobbies / pastimes / activities
- emotional coldness
- feeling of being overwhelmed at work or in personal situations [feeling out of control]
- inattentiveness
- sexual frustration
- lack of motivation
so what do we do with all these decidedly inelegant trappings? so far we have favoured escapism - preferring our own company, refusing opportunities for social outings, staying indoors with a book, auto-satisfaction... we also sometimes wonder whether we are like this due to tiredness, getting into situations or mindsets that create angst / torpor / feelings of inadequacy. we find ourself getting increasingly bogged down and stuck in a mindless routine that adds no value to our life.
we sometimes feel we need a goal. a focus. perhaps this should be explored.
the reason this post is in a blog on dobuy? our current lifestyle and situation emanate from our work conditions. which are not to our liking.
we will explore this further...
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